Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia
نویسندگان
چکیده
منابع مشابه
Deep Brain Stimulation of the Nucleus Basalis of Meynert in Early Stage of Alzheimer's Dementia.
ADAS-cog 1⁄4 Alzheimer’s disease Assessment Scale, MMSE 1⁄4Mini Mental Status Examination, RWT 1⁄4 Regensburger Wortschatz Test, WAIS 1⁄4 Wechsler Adult Intelligence Scale, WMS 1⁄4 Wechsler Memory Scale, BDI II 1⁄4 Beck’s Depression Inventory (2nd edition), HAMD 1⁄4 Hamilton Depression Rating Scale, FAST 1⁄4 Florida Apraxia Screening Test. a A lower value represents a better outcome. b A higher...
متن کاملStimulate or degenerate: deep brain stimulation of the nucleus basalis Meynert in Alzheimer dementia.
OBJECTIVE Deep brain stimulation (DBS) is a therapeutically effective neurosurgical method originally applied in movement disorders. Over time, the application of DBS has increasingly been considered as a therapeutic option for several neuropsychiatric disorders, including Gilles de la Tourette syndrome, obsessive compulsive disorder, major depression and addiction. Latest research suggests ben...
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The nucleus basalis of Meynert (NBM), a heterogeneous area in the basal forebrain involved in the modulation of sleep and wakefulness, is rich in glutamate receptors, and glutamatergic fibers represent an important part of the input to this nucleus. With the use of unilateral infusions in the NBM, the effects of two different glutamatergic subtype agonists, namely N-methyl-d-aspartic acid (NMDA...
متن کاملComparative analysis of the nucleus basalis of Meynert among primates.
Long projection axons from the Ch4 cell group of the nucleus basalis of Meynert (nbM) provide cholinergic innervation to the neurons of the cerebral cortex. This cortical cholinergic innervation has been implicated in behavioral and cognitive functions, including learning and memory. Recent evidence revealed differences among primate species in the pattern of cholinergic innervation specific to...
متن کاملThe effect of nucleus basalis magnocellularis deep brain stimulation on memory function in a rat model of dementia
BACKGROUND Deep brain stimulation has recently been considered a potential therapy in improving memory function. It has been shown that a change of neurotransmitters has an effect on memory function. However, much about the exact underlying neural mechanism is not yet completely understood. We therefore examined changes in neurotransmitter systems and spatial memory caused by stimulation of nuc...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2014
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2014.32